3NRM
Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 283 | 32558.3 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora kinase A, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, ARK-1, hARK1, Breast tumor-amplified kinase |
| 2 | A | N-(3-methylisothiazol-5-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine | non-polymer | 297.3 | 1 | Chemie (NRM) |
Sequence modifications
A: 126 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 121 | - | expression tag |
| Ala 122 | - | expression tag |
| Met 123 | - | expression tag |
| Gly 124 | - | expression tag |
| Ser 125 | - | expression tag |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32558.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 297.3 | |
| All* | Total formula weight | 32855.6 |
