3NPC
Crystal structure of JNK2 complexed with BIRB796
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase 9 | polymer | 364 | 41896.3 | 2 | UniProt (P45984) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase 9, MAPK 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55 |
| 2 | A, B | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA | non-polymer | 527.7 | 2 | Chemie (B96) | |||
| 3 | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 364 (UniProt: P45984)
| PDB | External Database | Details |
|---|---|---|
| Lys 3 | Asp 3 | engineered mutation |
| Val 6 | Cys 6 | engineered mutation |
| Asn 8 | Ser 8 | engineered mutation |
| Glu 14 | Gln 14 | engineered mutation |
| Ala 203 | Lys 203 | engineered mutation |
| Ala 204 | Glu 204 | engineered mutation |
| Ala 250 | Lys 250 | engineered mutation |
| Ala 251 | Lys 251 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83792.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1055.3 | |
| All* | Total formula weight | 84848.0 |
