3NOX
Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | polymer | 753 | 87450.8 | 2 | UniProt (Q53TN1) Pfam (PF00930) Pfam (PF00326) UniProt (by SIFTS) (P27487) In PDB | Homo sapiens (human) | Dipeptidylpeptidase IV |
2 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
4 | A, B | Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone | non-polymer | 420.3 | 2 | Chemie (6A5) | |||
5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 479 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: Q53TN1)
PDB | External Database | Details |
---|---|---|
Glu 37 | - | expression tag |
Phe 38 | - | expression tag |
Pro 767 | - | expression tag |
Leu 768 | - | expression tag |
Glu 769 | - | expression tag |
Gln 770 | - | expression tag |
Lys 771 | - | expression tag |
Leu 772 | - | expression tag |
Ile 773 | - | expression tag |
Ser 774 | - | expression tag |
Glu 775 | - | expression tag |
Glu 776 | - | expression tag |
Asp 777 | - | expression tag |
Leu 778 | - | expression tag |
Asn 779 | - | expression tag |
Ser 780 | - | expression tag |
Ala 781 | - | expression tag |
Val 782 | - | expression tag |
Asp 783 | - | expression tag |
His 784 | - | expression tag |
His 785 | - | expression tag |
His 786 | - | expression tag |
His 787 | - | expression tag |
His 788 | - | expression tag |
His 789 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 174901.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 3144.8 | |
All* | Total formula weight | 178895.2 |