3NMZ

Crystal structure of APC complexed with Asef

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	APC variant protein	polymer	458	50767.3	2	UniProt (Q4LE70) Pfam (PF18797) Pfam (PF00514) UniProt (by SIFTS) (P25054)	Homo sapiens (human)	Adenomatous Polyposis Coli
2	C, D (D, C)	Rho guanine nucleotide exchange factor 4	polymer	116	12641.6	2	UniProt (Q9NR80) Pfam (PF00018)	Homo sapiens (human)	APC-stimulated guanine nucleotide exchange factor, Asef
3	E, F, G, H (A, B, D, C)	water	water		18.0	127	Chemie (HOH)

Sequence modifications

A, B: 303 - 739 (UniProt: Q4LE70)

PDB	External Database	Details
Met 282	-	expression tag
Gly 283	-	expression tag
Ser 284	-	expression tag
Ser 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag
Ser 292	-	expression tag
Ser 293	-	expression tag
Gly 294	-	expression tag
Leu 295	-	expression tag
Val 296	-	expression tag
Pro 297	-	expression tag
Arg 298	-	expression tag
Gly 299	-	expression tag
Ser 300	-	expression tag
His 301	-	expression tag
Met 302	-	expression tag

D, C: 170 - 276 (UniProt: Q9NR80)

PDB	External Database	Details
Met 161	-	expression tag
Gly 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
Met 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	126817.8
All*	Total formula weight	126817.8

*Water molecules are not included.