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3NLP

Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'S,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Nitric oxide synthase, brainpolymer42248779.52UniProt (P29476)
Pfam (PF02898)
Rattus norvegicus (brown rat rat rats)BNOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Constitutive NOS, NC-NOS
2C, J
(A, B)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3D, H
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
4E, K
(A, B)
5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.22Chemie (H4B)
5F, L
(A, B)
6-{[(3S,4S)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-aminenon-polymer372.52Chemie (JSS)
6G, M
(A, B)
ACETATE IONnon-polymer59.02Chemie (ACT)
7I
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
8N, O
(A, B)
waterwater18.0284Chemie (HOH)
Sequence modifications
A, B: 297 - 718 (UniProt: P29476)
PDBExternal DatabaseDetails
Val 336Met 336engineered mutation
Asn 597Asp 597engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight97559.0
Non-Polymers*Number of molecules11
Total formula weight2828.1
All*Total formula weight100387.1
*Water molecules are not included.

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PDB entries from 2025-07-23

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