3NIG

The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Integrin alpha-IIb	polymer	457	49516.0	2	UniProt (P08514) Pfam (PF01839)	Homo sapiens (human)	Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, Integrin alpha-IIb heavy chain
2	B, D (B, D)	Integrin beta-3	polymer	471	51958.8	2	UniProt (P05106) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372)	Homo sapiens (human)	Platelet membrane glycoprotein IIIa, GPIIIa, CD61
3	E, G (E, H)	Monoclonal antibody 10E5 heavy chain	polymer	221	23766.5	2		Mus musculus (mouse)
4	F, H (F, L)	Monoclonal antibody 10E5 light chain	polymer	214	23332.7	2		Mus musculus (mouse)
5	I, K (G, J)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G62182OO)
6	J, L (I, K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	AA, BA, GA, HA, M... (C, D, A, B)	CALCIUM ION	non-polymer		40.1	12	Chemie (CA)
8	CA, Q, R (C, A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
9	DA, EA, JA, KA, S... (C, D, L, A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
10	FA, U (D, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
11	IA, X (D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
12	LA, MA, NA, OA, PA... (A, B, C, D, E...)	water	water		18.0	1227	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	297147.8
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	25
	Total formula weight	1824.6
All*	Total formula weight	300994.3

*Water molecules are not included.