3NID
The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Integrin alpha-IIb | polymer | 457 | 49516.0 | 2 | UniProt (P08514) Pfam (PF01839) | Homo sapiens (human) | Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, Integrin alpha-IIb heavy chain |
| 2 | B, D (B, D) | Integrin beta-3 | polymer | 471 | 51958.8 | 2 | UniProt (P05106) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) | Homo sapiens (human) | Platelet membrane glycoprotein IIIa, GPIIIa, CD61 |
| 3 | E, G (E, H) | Monoclonal antibody 10E5 heavy chain | polymer | 221 | 23766.5 | 2 | Mus musculus (mouse) | ||
| 4 | F, H (F, L) | Monoclonal antibody 10E5 light chain | polymer | 214 | 23332.7 | 2 | Mus musculus (mouse) | ||
| 5 | I (G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G21381MC) | |||
| 6 | J, L (I, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | K (J) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 8 | DA, EA, FA, GA, M... (C, A, D, B) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 9 | BA, HA, IA, Q, R... (B, C, A) | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
| 10 | CA, JA, KA, LA, MA... (B, C, D, H, L...) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 11 | NA, X (D, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 12 | AA, QA (B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 13 | AB, BB, CB, VA, WA... (F, H, L, A, B...) | water | water | 18.0 | 1059 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 297147.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 2761.4 | |
| All* | Total formula weight | 302255.4 |
