3N9Z
Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cholesterol side-chain cleavage enzyme | polymer | 487 | 56885.1 | 2 | UniProt (P05108) Pfam (PF00067) | Homo sapiens (human) | Cytochrome P450 11A1, CYPXIA1, Cytochrome P450(scc), Cholesterol desmolase |
| 2 | C, D (C, D) | Adrenodoxin | polymer | 123 | 13488.0 | 2 | UniProt (P10109) Pfam (PF00111) | Homo sapiens (human) | Adrenal ferredoxin, Ferredoxin-1, Hepatoredoxin |
| 3 | E, G (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 4 | F, H (A, B) | (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol | non-polymer | 402.7 | 2 | Chemie (HC9) | |||
| 5 | I, J (C, D) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 482 (UniProt: P05108)
| PDB | External Database | Details |
|---|---|---|
| His 483 | - | expression tag |
| His 484 | - | expression tag |
| His 485 | - | expression tag |
| His 486 | - | expression tag |
| His 487 | - | expression tag |
| His 488 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140746.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2389.9 | |
| All* | Total formula weight | 143136.1 |
