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3N68

Structure of endothelial nitric oxide synthase heme domain N368D/V106M double mutant complexed with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Nitric oxide synthasepolymer44449743.22UniProt (P29476)
Pfam (PF02898)
Bos taurus (cow)Endothelial NOS, eNOS, EC-NOS, NOS type III, NOSIII, Constitutive NOS, cNOS
2C, K
(A, B)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3D, L
(A, B)
5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.22Chemie (H4B)
4E, F
(A)
ACETATE IONnon-polymer59.02Chemie (ACT)
5G, M
(A, B)
GLYCEROLnon-polymer92.12Chemie (GOL)
6H, N
(A, B)
6-(2-{3-[2-(2-amino-6-methylpyridin-4-yl)ethyl]phenyl}ethyl)-4-methylpyridin-2-aminenon-polymer346.52Chemie (XFH)
7I, O
(A, B)
CACODYLIC ACIDnon-polymer138.02Chemie (CAD)
8J
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
9P, Q
(A, B)
waterwater18.096Chemie (HOH)
Sequence modifications
A, B: 39 - 482 (UniProt: P29476)
PDBExternal DatabaseDetails
Arg 100Cys 100SEE REMARK 999
Met 106Val 106engineered mutation
Asp 368Asn 368engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight99486.3
Non-Polymers*Number of molecules13
Total formula weight3052.1
All*Total formula weight102538.4
*Water molecules are not included.

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PDB entries from 2024-10-30

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