3N61
Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6,6'-(2,2'-(pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase | polymer | 422 | 48779.5 | 2 | UniProt (P29476) Pfam (PF02898) | Rattus norvegicus (rat) | Endothelial NOS, eNOS, EC-NOS, NOS type III, NOSIII, Constitutive NOS, cNOS |
| 2 | C, K (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, L (A, B) | 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine) | non-polymer | 347.5 | 2 | Chemie (XFJ) | |||
| 4 | E, M (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 5 | F, N (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | G, J, Q (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 7 | H, I, O, P (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 8 | R, S (A, B) | water | water | 18.0 | 403 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 718 (UniProt: P29476)
| PDB | External Database | Details |
|---|---|---|
| Val 336 | Met 336 | engineered mutation |
| Asn 597 | Asp 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97559.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2866.5 | |
| All* | Total formula weight | 100425.5 |
