3MZ4
Crystal structure of D101L Mn2+ HDAC8 complexed with M344
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Histone deacetylase 8 | polymer | 389 | 43230.1 | 2 | UniProt (Q9BY41) Pfam (PF00850) In PDB | Homo sapiens (human) | HD8 |
2 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
3 | A, B | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
4 | A, B | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 2 | Chemie (B3N) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | water | water | 18.0 | 553 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
PDB | External Database | Details |
---|---|---|
Leu 101 | Asp 101 | engineered mutation |
Ile 378 | - | expression tag |
Glu 379 | - | expression tag |
Gly 380 | - | expression tag |
Arg 381 | - | expression tag |
Gly 382 | - | expression tag |
Ser 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 86460.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1065.2 | |
All* | Total formula weight | 87525.4 |