3MWW

Crystal structure of HCV NS5B polymerase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Genome polyprotein	polymer	576	64285.6	2	UniProt (O92972) Pfam (PF00998) In PDB	Hepatitis C virus (HCV)	Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease/NTPase/helicase NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68
2	A, B	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	B	1-[2-(4-carboxypiperidin-1-yl)-2-oxoethyl]-3-cyclohexyl-2-furan-3-yl-1H-indole-6-carboxylic acid	non-polymer		478.5	1	Chemie (BIW)
4		water	water		18.0	65	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128571.3
Non-Polymers*	Number of molecules	4
	Total formula weight	766.7
All*	Total formula weight	129338.0

*Water molecules are not included.