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3MWW

Crystal structure of HCV NS5B polymerase

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Genome polyproteinpolymer57664285.62UniProt (O92972)
Pfam (PF00998)
Hepatitis C virus (HCV)Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease/NTPase/helicase NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68
2C, D, F
(A, B)
SULFATE IONnon-polymer96.13Chemie (SO4)
3E
(B)
1-[2-(4-carboxypiperidin-1-yl)-2-oxoethyl]-3-cyclohexyl-2-furan-3-yl-1H-indole-6-carboxylic acidnon-polymer478.51Chemie (BIW)
4G, H
(A, B)
waterwater18.065Chemie (HOH)
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
PDBExternal DatabaseDetails
His 571-expression tag
His 572-expression tag
His 573-expression tag
His 574-expression tag
His 575-expression tag
His 576-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight128571.3
Non-Polymers*Number of molecules4
Total formula weight766.7
All*Total formula weight129338.0
*Water molecules are not included.

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PDB entries from 2025-07-02

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