3MVR

Crystal Structure of cytochrome P450 2B4-H226Y in a closed conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cytochrome P450 2B4	polymer	476	54169.1	2	UniProt (P00178) Pfam (PF00067) In PDB	Oryctolagus cuniculus (rabbit)	CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
2	A, B	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	A, B	5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE	non-polymer		494.6	4	Chemie (CM5)
4		water	water		18.0	729	Chemie (HOH)

Sequence modifications

A, B: 20 - 491 (UniProt: P00178)

PDB	External Database	Details
Met 20	-	expression tag
Ala 21	-	expression tag
Lys 22	Gly 22	engineered mutation
Lys 23	His 23	engineered mutation
Thr 24	Pro 24	engineered mutation
Ser 25	Lys 25	engineered mutation
Ser 26	Ala 26	engineered mutation
Lys 27	His 27	engineered mutation
Lys 29	Arg 29	engineered mutation
Ser 221	Pro 221	engineered mutation
Tyr 226	His 226	engineered mutation
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108338.2
Non-Polymers*	Number of molecules	6
	Total formula weight	3211.3
All*	Total formula weight	111549.4

*Water molecules are not included.