3MVL
P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 14 | polymer | 366 | 42105.0 | 2 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 14, MAPK 14, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | C, D (A, B) | 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide | non-polymer | 406.5 | 2 | Chemie (38P) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Met -5 | - | expression tag |
| Ala -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84210.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 813.0 | |
| All* | Total formula weight | 85023.0 |
