3MV5
Crystal structure of Akt-1-inhibitor complexes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | v-akt murine thymoma viral oncogene homolog 1 (AKT1) | polymer | 342 | 39608.1 | 1 | UniProt (B2RAM5) Pfam (PF00069) Pfam (PF00433) UniProt (by SIFTS) (P31749) | Homo sapiens (human) | |
| 2 | B (C) | GSK3-beta peptide | polymer | 10 | 1123.2 | 1 | UniProt (by SIFTS) (P49841) | ||
| 3 | C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | D (A) | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine | non-polymer | 217.3 | 1 | Chemie (XFE) | |||
| 5 | E, F (A, C) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 144 - 480 (UniProt: B2RAM5)
| PDB | External Database | Details |
|---|---|---|
| Gly 139 | - | expression tag |
| Ala 140 | - | expression tag |
| Met 141 | - | expression tag |
| Asp 142 | - | expression tag |
| Pro 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40731.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 272.2 | |
| All* | Total formula weight | 41003.5 |
