3MTL
Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division protein kinase 16 | polymer | 324 | 37308.8 | 1 | UniProt (Q00536) Pfam (PF00069) | Homo sapiens (human) | Serine/threonine-protein kinase PCTAIRE-1, PCTAIRE-motif protein kinase 1 |
| 2 | B (A) | (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} | non-polymer | 365.4 | 1 | Chemie (FEF) | |||
| 3 | C (A) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 163 - 478 (UniProt: Q00536)
| PDB | External Database | Details |
|---|---|---|
| Met 162 | - | expression tag |
| Asp 319 | Ser 319 | engineered mutation |
| Ala 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
| His 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37308.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.4 | |
| All* | Total formula weight | 37674.2 |
