3MPM
LCK complexed with a pyrazolopyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Lck | polymer | 267 | 30656.2 | 1 | UniProt (P06239) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene Lck, Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, LSK, T cell-specific protein-tyrosine kinase |
| 2 | B (A) | 4-{(6R,7R)-7-amino-3-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl}phenol | non-polymer | 402.5 | 1 | Chemie (5LK) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 237 - 501 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Gly 235 | - | expression tag |
| Pro 236 | - | expression tag |
| Asn 364 | Asp 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30656.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 464.6 | |
| All* | Total formula weight | 31120.7 |
