3MP3

Crystal Structure of Human Lyase in complex with inhibitor HG-CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Hydroxymethylglutaryl-CoA lyase	polymer	298	31577.6	6	UniProt (P35914) Pfam (PF00682)	Homo sapiens (human)	HMG-CoA lyase, HL, 3-hydroxy-3-methylglutarate-CoA lyase
2	G (A)	3-HYDROXYPENTANEDIOIC ACID	non-polymer		148.1	1	Chemie (3HG)
3	H, J, K, L, M... (A, B, C, D, E...)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
4	I (B)	(3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide	non-polymer		897.6	1	Chemie (HGG)
5	O, P, Q, R, S... (A, B, C, D, E...)	water	water		18.0	437	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	189465.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1191.6
All*	Total formula weight	190657.3

*Water molecules are not included.