3MNO
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucocorticoid receptor | polymer | 261 | 30124.1 | 1 | UniProt (P06537) Pfam (PF00104) In PDB | Mus musculus (mouse) | GR, Nuclear receptor subfamily 3 group C member 1 |
2 | B | Nuclear receptor coactivator 2 peptide | polymer | 13 | 1593.8 | 1 | UniProt (Q61026) In PDB | NCoA-2, Transcriptional intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1 | |
3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | A | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) | |||
5 | A | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
6 | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A: 527 - 783 (UniProt: P06537)
PDB | External Database | Details |
---|---|---|
Gly 523 | - | expression tag |
Ser 524 | - | expression tag |
His 525 | - | expression tag |
Met 526 | - | expression tag |
Ser 608 | Phe 608 | engineered mutation |
Val 611 | Ala 611 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 31718.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 692.8 | |
All* | Total formula weight | 32410.8 |