3MNE
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by F608S mutation at 1.96A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 261 | 30096.1 | 1 | UniProt (P06537) Pfam (PF00104) | Mus musculus (mouse) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 peptide | polymer | 13 | 1593.8 | 1 | UniProt (Q61026) | NCoA-2, Transcriptional intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1 | |
| 3 | C, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | D (A) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A: 527 - 783 (UniProt: P06537)
| PDB | External Database | Details |
|---|---|---|
| Gly 523 | - | expression tag |
| Ser 524 | - | expression tag |
| His 525 | - | expression tag |
| Met 526 | - | expression tag |
| Ser 608 | Phe 608 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31689.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 576.6 | |
| All* | Total formula weight | 32266.6 |
