3MK8
The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17937.4 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3 |
| 2 | B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 21 | 2399.8 | 1 | UniProt (Q07820) In PDB | Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3 | |
| 3 | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 172 - 327 (UniProt: Q07820)
B: 4 - 24 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Mk8 17 | Gln 221 | engineered mutation |
| Mk8 21 | Glu 225 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20337.2 | |
| All* | Total formula weight | 20337.2 |
