3MJG

The structure of a platelet derived growth factor receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Platelet-derived growth factor subunit B	polymer	172	19596.3	2	UniProt (P01127) Pfam (PF04692) Pfam (PF00341)	Homo sapiens (human)	PDGF subunit B, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, PDGF-2, Proto-oncogene c-Sis
2	C, D (X, Y)	Beta-type platelet-derived growth factor receptor	polymer	289	32493.4	2	UniProt (P09619) Pfam (PF00047) Pfam (PF13927)	Homo sapiens (human)	PDGF-R-beta, CD140 antigen-like family member B
3	E (X)	2-acetamido-2-deoxy-alpha-D-glucopyranose	non-polymer		221.2	1	Chemie (NDG)
4	F, G, H, I, J... (X, Y)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)
5	S, T, U, V (A, B, X, Y)	water	water		18.0	1170	Chemie (HOH)

Sequence modifications

A, B: -60 - 104 (UniProt: P01127)

PDB	External Database	Details
His 105	-	expression tag
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag

X, Y: 33 - 314 (UniProt: P09619)

PDB	External Database	Details
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	104179.3
Non-Polymers*	Number of molecules	14
	Total formula weight	3096.9
All*	Total formula weight	107276.2

*Water molecules are not included.