3MIA

Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cell division protein kinase 9	polymer	351	40692.2	1	UniProt (P50750) Pfam (PF00069) In PDB	Homo sapiens (human)	Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, Cell division cycle 2-like protein kinase 4, C-2K
2	B	Cyclin-T1	polymer	266	30877.3	1	UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB	Homo sapiens (human)	Cyclin-T, CycT1
3	C	Protein Tat	polymer	86	9848.3	1	UniProt (P04608) Pfam (PF00539) In PDB	Human immunodeficiency virus type 1 (HIV-1)	Transactivating regulatory protein
4	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7		water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 1 - 345 (UniProt: P50750)

PDB	External Database	Details
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag

C: 1 - 86 (UniProt: P04608)

PDB	External Database	Details
Ser 77	Pro 77	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	81417.8
Non-Polymers*	Number of molecules	4
	Total formula weight	661.3
All*	Total formula weight	82079.1

*Water molecules are not included.