3MIA
Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division protein kinase 9 | polymer | 351 | 40692.2 | 1 | UniProt (P50750) Pfam (PF00069) | Homo sapiens (human) | Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, Cell division cycle 2-like protein kinase 4, C-2K |
| 2 | B (B) | Cyclin-T1 | polymer | 266 | 30877.3 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | Cyclin-T, CycT1 |
| 3 | C (C) | Protein Tat | polymer | 86 | 9848.3 | 1 | UniProt (P04608) Pfam (PF00539) | Human immunodeficiency virus type 1 (HIV-1) | Transactivating regulatory protein |
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 1 - 345 (UniProt: P50750)
C: 1 - 86 (UniProt: P04608)
| PDB | External Database | Details |
|---|---|---|
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| His 348 | - | expression tag |
| His 349 | - | expression tag |
| His 350 | - | expression tag |
| His 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 77 | Pro 77 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 81417.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 661.3 | |
| All* | Total formula weight | 82079.1 |
