3MGY

Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state

Replaces:  2PV5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 14	polymer	360	41343.2	1	UniProt (Q16539) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 14, MAPK 14, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2	B (A)	octyl beta-D-glucopyranoside	non-polymer		292.4	1	Chemie (BOG)
3	C (A)	water	water		18.0	53	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	41343.2
Non-Polymers*	Number of molecules	1
	Total formula weight	292.4
All*	Total formula weight	41635.6

*Water molecules are not included.