3MEG
HIV-1 K103N Reverse Transcriptase in Complex with TMC278
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | p66 Reverse transcriptase | polymer | 560 | 64547.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | HIV-1 M:B_HXB2R (HIV-1) | |
| 2 | B (B) | p51 Reverse transcriptase | polymer | 440 | 51384.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | HIV-1 M:B_HXB2R (HIV-1) | |
| 3 | C (A) | 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile | non-polymer | 366.4 | 1 | Chemie (T27) | |||
| 4 | D, E, F, G, H (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 690 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115931.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 846.7 | |
| All* | Total formula weight | 116778.6 |
