3MCF

Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Diphosphoinositol polyphosphate phosphohydrolase 3-alpha	polymer	136	15787.9	2	UniProt (Q8NFP7) Pfam (PF00293)	Homo sapiens (human)	DIPP-3-alpha, DIPP3-alpha, hDIPP3alpha, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha, Nucleoside diphosphate-linked moiety X motif 10, Nudix motif 10, hAps2
2	C, D (A, B)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
3	E (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	221	Chemie (HOH)

Sequence modifications

A, B: 17 - 144 (UniProt: Q8NFP7)

PDB	External Database	Details
Met 16	-	expression tag
Glu 90	Lys 90	engineered mutation
Ala 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31575.8
Non-Polymers*	Number of molecules	3
	Total formula weight	470.3
All*	Total formula weight	32046.1

*Water molecules are not included.