3M42
Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MAP kinase-activated protein kinase 2 | polymer | 299 | 34564.0 | 1 | UniProt (P49137) Pfam (PF00069) In PDB | Homo sapiens (human) | MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2 |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | 2-[5-(2-methoxyethoxy)pyridin-3-yl]-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin-7-one | non-polymer | 388.4 | 1 | Chemie (HGF) | |||
4 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 47 - 364 (UniProt: P49137)
PDB | External Database | Details |
---|---|---|
Gly 45 | - | expression tag |
Pro 46 | - | expression tag |
- | Ser 216 | deletion |
- | His 217 | deletion |
- | Asn 218 | deletion |
- | Ser 219 | deletion |
- | Leu 220 | deletion |
- | Thr 221 | deletion |
- | Thr 222 | deletion |
- | Pro 223 | deletion |
- | Cys 224 | deletion |
- | Tyr 225 | deletion |
- | Thr 226 | deletion |
- | Pro 227 | deletion |
- | Tyr 228 | deletion |
- | Tyr 229 | deletion |
- | Val 230 | deletion |
- | Ala 231 | deletion |
- | Pro 232 | deletion |
- | Glu 233 | deletion |
- | Val 234 | deletion |
- | Leu 235 | deletion |
- | Gly 236 | deletion |
Gly 237 | Pro 237 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34564.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 412.7 | |
All* | Total formula weight | 34976.8 |