3M3Z
Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock cognate 71 kDa protein | polymer | 381 | 42086.5 | 1 | UniProt (P11142) Pfam (PF00012) | Homo sapiens (human) | Heat shock 70 kDa protein 8 |
| 2 | B (B) | BAG family molecular chaperone regulator 1 | polymer | 114 | 13157.2 | 1 | UniProt (Q99933) Pfam (PF02179) | Homo sapiens (human) | BAG-1, Bcl-2-associated athanogene 1 |
| 3 | C (A) | 5'-O-(2-amino-2-oxoethyl)-8-(methylamino)adenosine | non-polymer | 353.3 | 1 | Chemie (3F5) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
A: 4 - 381 (UniProt: P11142)
B: 151 - 263 (UniProt: Q99933)
| PDB | External Database | Details |
|---|---|---|
| Tyr 1 | - | expression tag |
| Phe 2 | - | expression tag |
| Gln 3 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55243.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 353.3 | |
| All* | Total formula weight | 55597.0 |
