3M11
Crystal Structure of Aurora A Kinase complexed with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 279 | 32359.1 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora kinase A, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, ARK-1, hARK1, Breast tumor-amplified kinase |
| 2 | A | 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea | non-polymer | 525.6 | 1 | Chemie (AKI) | |||
| 3 | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A: 123 - 401 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Asp 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32359.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 525.6 | |
| All* | Total formula weight | 32884.7 |
