3LZU
Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | HIV-1 protease | polymer | 99 | 10739.8 | 2 | UniProt (Q9QB59) Pfam (PF00077) UniProt (by SIFTS) (P24740) In PDB | Human immunodeficiency virus 1 | |
| 2 | B, A | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 3 | A | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 4 | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: Q9QB59)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Ser 88 | Asn 88 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21479.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 842.9 | |
| All* | Total formula weight | 22322.4 |
