3LZB
EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Epidermal growth factor receptor | polymer | 327 | 36137.5 | 8 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Receptor tyrosine-protein kinase erbB-1, c-erbB-1 |
| 2 | I, J, K, L (A, B, C, D) | N-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | non-polymer | 587.7 | 4 | Chemie (ITI) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 289099.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2350.8 | |
| All* | Total formula weight | 291450.6 |
