3LY2

Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	polymer	357	41020.3	8	UniProt (Q07343) Pfam (PF00233)	Homo sapiens (human)	DPDE4, PDE32
2	CA, FA, I, M, Q... (G, H, A, B, C...)	8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one	non-polymer		421.3	8	Chemie (Z72)
3	AA, DA, GA, J, N... (F, G, H, A, B...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4	BA, EA, HA, K, O... (F, G, H, A, B...)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	L, P (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	IA, JA, KA, LA, MA... (A, B, C, D, E...)	water	water		18.0	494	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 152 - 487 (UniProt: Q07343)

PDB	External Database	Details
Met 131	-	expression tag
Gly 132	-	expression tag
Ser 133	-	expression tag
Ser 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
Ser 141	-	expression tag
Ser 142	-	expression tag
Gly 143	-	expression tag
Leu 144	-	expression tag
Val 145	-	expression tag
Pro 146	-	expression tag
Arg 147	-	expression tag
Gly 148	-	expression tag
Ser 149	-	expression tag
His 150	-	expression tag
Met 151	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	328162.8
Non-Polymers*	Number of molecules	26
	Total formula weight	4280.0
All*	Total formula weight	332442.8

*Water molecules are not included.