3LVP

Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Insulin-like growth factor 1 receptor	polymer	336	38469.2	4	UniProt (P08069) Pfam (PF07714)	Homo sapiens (human)	IGF1R, Insulin-like growth factor I receptor, IGF-I receptor, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain
2	E, H, J, K (A, B, C, D)	3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine	non-polymer		342.8	4	Chemie (PDR)
3	F (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
4	G, I (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	L, M, N, O (A, B, C, D)	water	water		18.0	13	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153876.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1801.6
All*	Total formula weight	155678.2

*Water molecules are not included.