3LQG
Human aldose reductase mutant T113A complexed with IDD388
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldose reductase | polymer | 316 | 35868.3 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (human) | AR, Aldehyde reductase, Aldo-keto reductase family 1 member B1 |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (46936685) | |||
| 3 | C (A) | (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID | non-polymer | 416.6 | 1 | Chemie (388) PubChem (16058629) | |||
| 4 | D (A) | BROMIDE ION | non-polymer | 79.9 | 1 | Chemie (BR) PubChem (259) | |||
| 5 | E (A) | water | water | 18.0 | 437 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | SEE REMARK 999 |
| Ala 113 | Thr 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35868.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1239.9 | |
| All* | Total formula weight | 37108.2 |
