3LQ8
Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 302 | 34201.6 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | B (A) | N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | non-polymer | 632.7 | 1 | Chemie (88Z) | |||
| 3 | C (A) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1348 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1049 | - | expression tag |
| Ser 1050 | - | expression tag |
| Glu 1349 | - | expression tag |
| Phe 1350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34201.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 632.7 | |
| All* | Total formula weight | 34834.3 |
