3LPO

Crystal structure of the N-terminal domain of sucrase-isomaltase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Sucrase-isomaltase	polymer	898	102867.1	4	UniProt (P14410) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365)	Homo sapiens (human)	Sucrase, Isomaltase
2	E, G (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	F, H (F, H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
4	I, J, K, L, M (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)

Sequence modifications

A, B, C, D: 29 - 898 (UniProt: P14410)

PDB	External Database	Details
Arg 1	-	expression tag
Ser 2	-	expression tag
Ser 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Gly 10	-	expression tag
Glu 11	-	expression tag
Phe 12	-	expression tag
Asp 13	-	expression tag
Ile 14	-	expression tag
Pro 15	-	expression tag
Thr 16	-	expression tag
Thr 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Ser 24	-	expression tag
Gly 25	-	expression tag
Ile 26	-	expression tag
Arg 27	-	expression tag
Arg 28	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	411468.6
Branched	Number of molecules	4
	Total formula weight	2670.4
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	415245.1

*Water molecules are not included.