3LKW
Crystal Structure of Dengue Virus 1 NS2B/NS3 protease active site mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | fusion protein of nonstructural protein 2B and nonstructural protein 3 | polymer | 236 | 25046.9 | 1 | UniProt (P33478) UniProt (P17763) Pfam (PF01002) Pfam (PF00949) In PDB | Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1) | |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A | CADMIUM ION | non-polymer | 112.4 | 1 | Chemie (CD) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 5 - 51 (UniProt: P33478)
A: 61 - 236 (UniProt: P17763)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| His 3 | - | expression tag |
| Met 4 | - | expression tag |
| Gly 52 | - | linker |
| Gly 53 | - | linker |
| Gly 54 | - | linker |
| Gly 55 | - | linker |
| Ser 56 | - | linker |
| Gly 57 | - | linker |
| Gly 58 | - | linker |
| Gly 59 | - | linker |
| Gly 60 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| - | Pro 1486 | deletion |
| - | Glu 1487 | deletion |
| - | Val 1488 | deletion |
| - | Glu 1489 | deletion |
| - | Arg 1490 | deletion |
| - | Ala 1491 | deletion |
| - | Val 1492 | deletion |
| - | Leu 1493 | deletion |
| - | Asp 1494 | deletion |
| - | Asp 1495 | deletion |
| Ala 185 | Ser 1610 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25046.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 336.0 | |
| All* | Total formula weight | 25382.9 |
