3LJU

Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (X)	Arf-GAP with dual PH domain-containing protein 1	polymer	386	44999.8	1	UniProt (O75689) Pfam (PF01412) Pfam (PF00169)	Homo sapiens (human)	Centaurin-alpha-1, Cnt-a1, Putative MAPK-activating protein PM25
2	B (X)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C, D (X)	(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate	non-polymer		826.5	2	Chemie (IP9)
4	E (X)	water	water		18.0	294	Chemie (HOH)

Sequence modifications

X: 3 - 370 (UniProt: O75689)

PDB	External Database	Details
Met -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Arg -5	-	expression tag
Glu -4	-	expression tag
Asn -3	-	expression tag
Leu -2	-	expression tag
Tyr -1	-	expression tag
Phe 0	-	expression tag
Gln 1	-	expression tag
Gly 2	-	expression tag
Ser 241	Gly 241	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	44999.8
Non-Polymers*	Number of molecules	3
	Total formula weight	1718.5
All*	Total formula weight	46718.3

*Water molecules are not included.