3LFC
Human p38 MAP Kinase in Complex with RL99
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 14 | polymer | 360 | 41235.0 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | A | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 3 | A | (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid | non-polymer | 533.6 | 1 | Chemie (Z86) | |||
| 4 | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A: 2 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 119 | Cys 119 | engineered mutation |
| Ser 162 | Cys 162 | engineered mutation |
| Cys 172 | Ala 172 | engineered mutation |
| Leu 327 | Phe 327 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41235.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 826.0 | |
| All* | Total formula weight | 42061.0 |
