3LDP
Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 78 kDa glucose-regulated protein | polymer | 384 | 42299.9 | 2 | UniProt (P11021) Pfam (PF00012) | Homo sapiens (human) | GRP 78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 |
| 2 | C, D (A, B) | 8-[(quinolin-2-ylmethyl)amino]adenosine | non-polymer | 423.4 | 2 | Chemie (3P1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 259 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 407 (UniProt: P11021)
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | expression tag |
| Ser 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84599.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 846.9 | |
| All* | Total formula weight | 85446.6 |
