3LCO
Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor | polymer | 324 | 36280.6 | 1 | UniProt (P07333) Pfam (PF07714) | Homo sapiens (human) | CSF-1-R, Proto-oncogene c-Fms |
| 2 | B (A) | 3-({4-methoxy-5-[(4-methoxybenzyl)oxy]pyridin-2-yl}methoxy)-5-(1-methyl-1H-pyrazol-4-yl)pyrazin-2-amine | non-polymer | 448.5 | 1 | Chemie (LC0) |
Sequence modifications
A: 550 - 741 (UniProt: P07333)
A: 742 - 919 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Ala 734 | Ser 688 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36280.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 448.5 | |
| All* | Total formula weight | 36729.0 |
