3LCD
Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Macrophage colony-stimulating factor 1 receptor | polymer | 329 | 37333.8 | 1 | UniProt (P07333) Pfam (PF07714) In PDB | Homo sapiens (human) | CSF-1-R, Fms proto-oncogene, c-fms |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | N~3~-(2,6-dichlorobenzyl)-5-(4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}phenyl)pyrazine-2,3-diamine | non-polymer | 525.5 | 1 | Chemie (BDY) | |||
| 4 | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 538 - 681 (UniProt: P07333)
A: 741 - 919 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Gly 535 | - | EXPRESSION TAG |
| Val 536 | - | EXPRESSION TAG |
| Asp 537 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37333.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 717.6 | |
| All* | Total formula weight | 38051.4 |
