3LC5
Selective Benzothiophine Inhibitors of Factor IXa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor IX | polymer | 235 | 26190.8 | 1 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (human) | Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain |
| 2 | B (B) | Coagulation factor IX | polymer | 57 | 6256.1 | 1 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (human) | Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain |
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | 1-{4-[(R)-phenyl(3-phenyl-1,2,4-oxadiazol-5-yl)methoxy]-1-benzothiophen-2-yl}methanediamine | non-polymer | 428.5 | 1 | Chemie (IZX) | |||
| 5 | E (A) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
B: 87 - 142 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Met 86 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32447.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 468.6 | |
| All* | Total formula weight | 32915.5 |
