3LBZ
Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-cell lymphoma 6 protein | polymer | 127 | 14559.8 | 2 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (human) | BCL-6, Zinc finger protein 51, LAZ-3 protein, BCL-5, Zinc finger and BTB domain-containing protein 27 |
| 2 | C, F (A, B) | N-[(4-bromophenyl)sulfonyl]acetamide | non-polymer | 278.1 | 2 | Chemie (Z88) | |||
| 3 | D, E, G (A, B) | (2R)-2-[(5Z)-5-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanedioic acid | non-polymer | 457.3 | 3 | Chemie (Z89) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29119.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1928.1 | |
| All* | Total formula weight | 31047.7 |
