3LBZ
Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | B-cell lymphoma 6 protein | polymer | 127 | 14559.8 | 2 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (human) | BCL-6, Zinc finger protein 51, LAZ-3 protein, BCL-5, Zinc finger and BTB domain-containing protein 27 |
2 | A, B | N-[(4-bromophenyl)sulfonyl]acetamide | non-polymer | 278.1 | 2 | Chemie (Z88) | |||
3 | A, B | (2R)-2-[(5Z)-5-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanedioic acid | non-polymer | 457.3 | 3 | Chemie (Z89) | |||
4 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 129 (UniProt: P41182)
PDB | External Database | Details |
---|---|---|
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Gln 8 | Cys 8 | engineered mutation |
Arg 67 | Cys 67 | engineered mutation |
Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29119.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1928.1 | |
All* | Total formula weight | 31047.7 |