3L81
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | AP-4 complex subunit mu-1 | polymer | 301 | 33112.6 | 1 | UniProt (O00189) Pfam (PF00928) In PDB | Homo sapiens (human) | Adapter-related protein complex 4 mu-1 subunit, AP-4 adapter complex mu subunit, Mu subunit of AP-4, Mu4-adaptin, mu4, Mu-adaptin-related protein 2, mu-ARP2 |
2 | B | Amyloid beta A4 protein | polymer | 7 | 963.1 | 1 | UniProt (P05067) In PDB | Alzheimer disease amyloid protein, ABPP, APPI, APP, PreA4, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Gamma-CTF(59), Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-secretase C-terminal fragment 57, Gamma-CTF(57), Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-secretase C-terminal fragment 50, Gamma-CTF(50), Amyloid intracellular domain 50, AICD-50, AID(50), C31 | |
3 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
4 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 160 - 453 (UniProt: O00189)
PDB | External Database | Details |
---|---|---|
Gly 153 | - | expression tag |
Ala 154 | - | expression tag |
Met 155 | - | expression tag |
Asp 156 | - | expression tag |
Pro 157 | - | expression tag |
Glu 158 | - | expression tag |
Phe 159 | - | expression tag |
Ser 235 | Cys 235 | engineered mutation |
Ser 431 | Cys 431 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 34075.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 276.3 | |
All* | Total formula weight | 34352.0 |