3L6C

X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine racemase	polymer	339	36579.7	2	UniProt (Q76EQ0) Pfam (PF00291)	Rattus norvegicus (rat)
2	C, F (A, B)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
3	D, G (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	E, H (A, B)	MALONATE ION	non-polymer		102.0	2	Chemie (MLI)
5	I, J (A, B)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A, B: 1 - 333 (UniProt: Q76EQ0)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73159.4
Non-Polymers*	Number of molecules	6
	Total formula weight	808.3
All*	Total formula weight	73967.7

*Water molecules are not included.