3L5U
Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Macrophage migration inhibitory factor | polymer | 122 | 13426.2 | 3 | UniProt (P14174) Pfam (PF01187) | Homo sapiens (human) | MIF, Phenylpyruvate tautomerase, L-dopachrome tautomerase, L-dopachrome isomerase, Glycosylation-inhibiting factor, GIF |
| 2 | D, F, H (A, B, C) | 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE | non-polymer | 230.3 | 3 | Chemie (ZEC) | |||
| 3 | E, G, I (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 114 (UniProt: P14174)
| PDB | External Database | Details |
|---|---|---|
| Leu 115 | - | expression tag |
| Glu 116 | - | expression tag |
| His 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| His 120 | - | expression tag |
| His 121 | - | expression tag |
| His 122 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 40278.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 979.0 | |
| All* | Total formula weight | 41257.6 |
