3L54
Structure of Pi3K gamma with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 966 | 110715.1 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PI3-kinase p110 subunit gamma, PtdIns-3-kinase subunit p110, PI3Kgamma, PI3K, p120-PI3K |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 6-(1H-pyrazolo[3,4-b]pyridin-5-yl)-4-pyridin-4-ylquinoline | non-polymer | 323.4 | 1 | Chemie (LXX) | |||
| 4 | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | initiating methionine |
| Gln 295 | His 295 | conflict |
| Leu 777 | Ser 777 | conflict |
| Asn 778 | Gln 778 | conflict |
| Val 1012 | Ile 1012 | conflict |
| His 1103 | - | expression tag |
| His 1104 | - | expression tag |
| His 1105 | - | expression tag |
| His 1106 | - | expression tag |
| His 1107 | - | expression tag |
| His 1108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 110715.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 419.4 | |
| All* | Total formula weight | 111134.5 |
