3L4C

Structural basis of membrane-targeting by Dock180

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dedicator of cytokinesis protein 1	polymer	220	24671.8	2	UniProt (Q14185) Pfam (PF14429) In PDB	Homo sapiens (human)	180 kDa protein downstream of CRK, DOCK180
2	A, B	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
3		water	water		18.0	70	Chemie (HOH)

Sequence modifications

A, B: 422 - 619 (UniProt: Q14185)

PDB	External Database	Details
Met 400	-	expression tag
Gly 401	-	expression tag
Ser 402	-	expression tag
Ser 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
Ser 410	-	expression tag
Ser 411	-	expression tag
Gly 412	-	expression tag
Leu 413	-	expression tag
Val 414	-	expression tag
Pro 415	-	expression tag
Arg 416	-	expression tag
Gly 417	-	expression tag
Ser 418	-	expression tag
His 419	-	expression tag
Met 420	-	expression tag
Pro 421	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49343.5
Non-Polymers*	Number of molecules	2
	Total formula weight	156.3
All*	Total formula weight	49499.8

*Water molecules are not included.