3L3N
Testis ACE co-crystal structure with novel inhibitor lisW
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Angiotensin-converting enzyme | polymer | 591 | 68281.2 | 1 | UniProt (P12821) Pfam (PF01401) | Homo sapiens (human) | ACE, Dipeptidyl carboxypeptidase I, Kininase II, Angiotensin-converting enzyme, soluble form |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F (A) | N~2~-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-tryptophan | non-polymer | 494.6 | 1 | Chemie (LSW) | |||
| 6 | G (A) | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A: 37 - 627 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gly 64 | Glu 669 | engineered mutation |
| Gln 90 | Asn 695 | engineered mutation |
| Gln 155 | Asn 760 | engineered mutation |
| Gln 337 | Asn 942 | engineered mutation |
| Gln 586 | Asn 1191 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 68281.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 630.9 | |
| All* | Total formula weight | 69482.7 |
